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Microbiomes in Transition

Focus Area and Projects

MinT is focused on key biosystems where microbiomes play important but poorly defined roles. Scientists at PNNL will leverage expertise and state-of-the-art technologies, including bioscience expertise across the Laboratory, PNNL's Marine Sciences Laboratory, and the Environmental Molecular Sciences Laboratory to address key knowledge gaps. These technologies include multi-omics, imaging, and computing.

MinT Thrust Areas Applications Computational Biology Integrated Omics

ApplicationsFocus Area 1: Applications

The focus is on ecosystems impacted by changes in hydrology caused by climate change. These include wetlands in boreal areas and coastal marine and river systems. In turn, this knowledge will enable better predictions of the impacts of climate change on ecosystem sustainability. See related projects.

Computational BiologyFocus Area 2: Computational Biology

The focus is on understanding how exposure to environmental agents, including radiation, chemicals, and drugs, impact the human microbiome and its metabolic functions. In turn, this new knowledge provides a mechanistic understanding of how changes in the microbiome contribute to individual susceptibility to environmental exposures. See related projects.

Integrated OmicsFocus Area 3: Integrated Omics

The focus is on gaining an understanding of the complex interactions and metabolic networks that function in microbiomes. We are applying our expertise in computational biology, bioinformatics, and statistics to develop new approaches to analyze increasingly large microbiome datasets, and to build models to capture and predict their behavior. See related projects.

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